In October of 1904, Aaron Brown and eight of his friends founded Phi Delta Epsilon at Cornell University Medical College. During the first decade of this century there were many doors closed to Jewish medical students and physicians, doors which would not fully open until after World War II. In 1904, it was not uncommon for American medical schools to have quotas limiting admission of Jewish students, and medical fraternities. So Aaron Brown and his friends decided they would start their own fraternal organization, guided by the precepts of philanthropy, deity, and equity.

The success of the Cornell chapter soon led to the organization of other chapters in the East and Midwest. In 1918, Phi Delta Epsilon amalgamated with Alpha Phi Sigma, a medical fraternity organized in 1908, whose ideals and principles were similar to those of PhiDE. Its chapters were in the Midwest and West, making for an ideal union...
— Phi Delta Epsilon National Website

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